Synthesis of F-18 labeled resazurin by direct electrophilic fluorination
نویسندگان
چکیده
منابع مشابه
Cu(I)-mediated (18)F-trifluoromethylation of arenes: rapid synthesis of (18)F-labeled trifluoromethyl arenes.
This report is concerned with an efficient, Cu(I)-mediated method for the radiosynthesis of [(18)F]trifluoromethyl arenes, abundant motifs in small molecule drug candidates and potential radiotracers for positron emission tomography. Three (18)F-labelled radiotracer candidates were synthesised from [(18)F]fluoride ions as proof of principle. The new protocol is widely applicable for the synthes...
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The electrophilic fluorination of several (triphos)Pt-aryl(+) establishes the first example of aryl-F coupling from a Pt center.
متن کاملStereospecific Electrophilic Fluorination of Alkylcarbastannatrane Reagents.
We report the use of isolable primary and secondary alkylcarbastannatrane nucleophiles in site-specific fluorination reactions. These reactions occur without the need for transition metal catalysis or in situ activation of the nucleophile. In the absence of the carbastannatrane backbone, alkyltin nucleophiles exhibit no activity towards fluorination. When enantioenriched alkylcarbastannatranes ...
متن کاملA fluoride-derived electrophilic late-stage fluorination reagent for PET imaging.
The unnatural isotope fluorine-18 ((18)F) is used as a positron emitter in molecular imaging. Currently, many potentially useful (18)F-labeled probe molecules are inaccessible for imaging because no fluorination chemistry is available to make them. The 110-minute half-life of (18)F requires rapid syntheses for which [(18)F]fluoride is the preferred source of fluorine because of its practical ac...
متن کاملSynthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.
UNLABELLED Elevated levels of choline (trimethyl-2-hydroxyethylammonium) and choline kinase (CK) activity in neoplasms have motivated the development of positron-labeled choline analogs for noninvasive detection of cancer using PET. The aim of this study was to further evaluate [(18)F]fluorocholine (fluoromethyl-dimethyl-2-hydroxyethylammonium [FCH]) as an oncologic probe in comparison with sev...
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ژورنال
عنوان ژورنال: Journal of Fluorine Chemistry
سال: 2015
ISSN: 0022-1139
DOI: 10.1016/j.jfluchem.2015.07.017